Development of a microfluidic device for measurement of distribution behavior between supercritical carbon dioxide and water.

Measurement and Modeling of Acridine Solubility in Supercritical Carbon Dioxide

Supercritical carbon dioxide has gained increasing attention in food and pharmaceutical processing owing to the fact that it is environmentally inexpensive, not flammable, essentially non-toxic, and it has a convenient critical point. Also, it has been attracting much attention in many fields, such as extraction of sensitive materials and pharmaceutical processing and polymerization processes. ...

Measurement and Correlation of Ibuprofen in Supercritical Carbon Dioxide Using Stryjek and Vera EOS

Dispersion Coefficients of Supercritical Fluid in Fixed Beds

The axial dispersion coefficient of hexachlorobenzene in supercritical carbon dioxide is investigated in a fixed-bed packed with glass beads. The on-line chromatographic pulse-response experiment is used in order to study the dynamics of a packed column under supercritical conditions. The radial dispersion is assumed negligible because of the packed column geometry. To estimate the axial disper...

Solubility Prediction of Drugs in Supercritical Carbon Dioxide Using Artificial Neural Network

The descriptors computed by HyperChem® software were employed to represent the solubility of 40 drug molecules in supercritical carbon dioxide using an artificial neural network with the architecture of 15-4-1. The accuracy of the proposed method was evaluated by computing average of absolute error (AE) of calculated and experimental logarithm of solubilities. The AE (±SD) of data sets was 0.4 ...

Continuous Synthesis of Oleyl Oleate in Supercritical Carbon Dioxide using Solid p-Toluenesulfonic Acid as Catalyst

Supercritical carbon dioxide (SC-CO2) was used as solvent to synthesize oleyl oleate as an analog of Jojoba oil from oleic acid and oleyl alcohol with high conversion (100%) of the acid into ester in a short time of 100 min. Utilizing a low cost solid catalyst, p-toluenesulfonic acid monohydrate (PTSA), the esterification reaction was performed, without any prior preparation step...